Longevity Science · Research summary
Antioxidant pathways in skin cells
← Longevity Science · Preclinical research · 2023
Equine placental extract activated antioxidant signalling and lowered selected inflammatory markers in cultured skin cells exposed to UVB.
Extract applied directly to cultured human skin cells; not an oral pet supplementation trial.
What the researchers observed
The study reports lower TNF-α and IL-6 mRNA, Nrf2 activation and higher HO-1 mRNA in the tested cells. Other inflammatory markers did not respond in the same way.
How this connects to your routine
Useful for explaining a research pathway, not for claiming the products prevent sun damage or treat inflammatory disease.
Understanding the study
- Study design: Laboratory experiments in HaCaT cells
- Participants or model: Cultured human epidermal keratinocytes exposed to UVB
- Preparation: Enzymatically processed, freeze-dried equine placental extract added directly to cell culture.
What this study cannot tell us
This is a cell study, not an oral supplementation trial in pets. A change in a laboratory marker does not establish clinical skin protection or an equivalent effect in dogs and cats.
Read the original research
The Effect of Equine Placental Extract on Anti-inflammatory and Anti-oxidant Activity of the Skin
Moriwaki, Takabuchi, Tsuruta, Ozawa, Hirano and Ando
Japanese Journal of Complementary and Alternative Medicine · 20(1):19–23 · 2023
DOI: 10.1625/jcam.20.19 ↗
Read full paper ↗ · Publisher or repository record ↗
Research relationships
The paper states that the work was conducted with funding from Japan Bio Products.
Explore the everyday concerns
Back to the reading library · Compare our placenta collection
Research findings depend on the preparation, species and study design. These summaries provide context for informed conversations with your veterinarian; research doses do not replace product label directions.