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← Longevity Science · Case reports · 2026
Five of six older dogs had lower cognitive-dysfunction questionnaire scores at day 49, following four weeks of oral equine placental extract supplementation.
Six dogs; owner-reported scores and no comparison group. Lower scores indicate fewer reported cognitive signs.
What the researchers observed
The report describes lower cognitive scores in most dogs, with no serious adverse events reported. Changes in other owner-rated measures were variable.
How this connects to your routine
This research relates to changes in an older dog’s behaviour and familiar routines. It supports further investigation alongside veterinary assessment, rather than a promise of cognitive recovery.
Understanding the study
- Study design: Uncontrolled six-case series
- Participants or model: Six dogs aged 10 years or older with cognitive dysfunction
- Preparation: Oral JBP equine placental extract; not a trial of all six retail products.
What this study cannot tell us
A small, uncontrolled series cannot establish cause and effect. Owner assessments are subjective, and the findings do not establish dementia prevention, reversal or long-term safety.
Read the original research
Equine placental extract supplementation in six elderly dogs with cognitive dysfunction: A six-case series
Mami Irimajiri, Kentarou Tahara and Eiichi Hirano
Open Veterinary Journal · 16(6):4089–4097 · 2026
DOI: 10.5455/OVJ.2026.v16.i6.75 ↗
Read full paper ↗ · Publisher or repository record ↗
Research relationships
Japan Bio Products funded the study. Tahara and Hirano are employees; Irimajiri reports a consulting agreement established after the study.
Explore the everyday concerns
Back to the reading library · Compare our placenta collection
Research findings depend on the preparation, species and study design. These summaries provide context for informed conversations with your veterinarian; research doses do not replace product label directions.