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← Longevity Science · Preclinical research · 2025
In mice with adenine-induced kidney injury, oral equine placental extract was associated with lower indoxyl sulfate levels and reduced measures of kidney tissue injury, fibrosis and inflammatory-cell accumulation.
A 14-day laboratory mouse study, not a clinical trial in dogs or cats. It does not establish a treatment or preventive benefit for pets with kidney disease.
What the researchers observed
Compared with mice receiving the adenine diet alone, mice also given the extract had lower indoxyl sulfate levels in blood, kidney and liver samples. Kidney tissue assessments showed lower injury scores, less fibrosis staining and fewer F4/80-positive macrophages, a marker of inflammatory-cell accumulation. A separate rat-liver preparation assay found reduced indoxyl sulfate production.
How this connects to your routine
This paper expands the laboratory research in our reading library. It investigates a pathway involving indoxyl sulfate, a waste compound that can accumulate when kidney function is impaired. It does not show that a retail placenta supplement supports kidney function in dogs or cats, or replaces veterinary kidney care.
Understanding the study
- Study design: Controlled laboratory experiment. The methods describe 24 male ICR mice randomly assigned to three groups of eight: normal diet, adenine diet, and adenine diet plus extract. Treatment lasted 14 days.
- Participants or model: Adenine-induced kidney injury in seven-week-old mice, with a separate assay using a rat-liver S9 fraction. No pet dogs or cats were enrolled.
- Preparation: Pepsin-digested, filtered, heat-treated and freeze-dried equine placental extract, administered orally in the mouse experiment. This was not a trial of the finished retail products.
What this study cannot tell us
The study measured biochemical and tissue changes in a short, experimentally induced disease model. It does not establish clinical effectiveness, long-term safety, improved survival or an appropriate serving amount for pets. The authors call for clinical trials to investigate efficacy, safety and mechanism.
Read the original research
The equine placental extract ameliorates renal damage in mice with adenine-induced chronic kidney disease by inhibiting indoxyl sulfate production
Koji Sugimoto, Junichi Nakamura, Dawei Deng and Eiichi Hirano
Open Veterinary Journal · 15(7):3334–3340 · 2025
DOI: 10.5455/OVJ.2025.v15.i7.45 ↗
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Research relationships
Japan Bio Products funded the study. All four authors are employees of Japan Bio Products; the paper also states that the authors declare no conflict of interest.
Back to the reading library · Compare our placenta collection
Research findings depend on the preparation, species and study design. These summaries provide context for informed conversations with your veterinarian; research doses do not replace product label directions.